Norethindrone (Contraceptive)
Drug Information
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
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Manganese
Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.
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Vitamin B6
Laboratory evidence of vitamin B6 deficiency is common in women taking oral contraceptives.
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Magnesium
Women using oral contraceptives were found to have significantly lower serum magnesium levels in a controlled study. In a preliminary study, blood levels of magnesium decreased in women taking an oral contraceptive containing ethinyl estradiol and levonorgestrel. Although the importance of this interaction remains somewhat unclear, supplementation with 250 to 350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence. -
Vitamin B12
A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2 , B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence. -
Vitamin B2
A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2 , B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence. -
Vitamin C
A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2 , B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Reduce Side Effects
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Vitamin B6
In a double-blind trial, supplementation with 20 mg of vitamin B6 twice a day for 2 months improved depression in women taking oral contraceptives who had laboratory evidence of vitamin B6 deficiency. However, vitamin B6 did not relieve depression in women who did not have vitamin B6 deficiency.
Support Medicine
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Calcium
A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2 , B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.
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Copper
A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2 , B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.
Reduces Effectiveness
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none
Potential Negative Interaction
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none
Explanation Required
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Iron
Menstrual blood loss is typically reduced with use of oral contraceptives. This can lead to increased iron stores and, presumably, a decreased need for iron in premenopausal women. Premenopausal women taking oral contraceptives should have their iron levels monitored and talk with their prescribing doctor before using iron-containing supplements.
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Vitamin A
A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2 , B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.
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Last Review: 03-24-2015
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2020.