Chromosome 10, Monosomy 10p
National Organization for Rare Disorders, Inc.
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General Discussion
Chromosome 10, monosomy 10p is a rare chromosomal disorder in which the end (distal) portion of the short arm (p) of chromosome 10 is missing (deleted or monosomic). The range and severity of symptoms and findings may be variable, depending upon the exact size or location of the deletion on chromosome 10p. However, associated features often include severe intellectual disability; growth delays after birth (postnatal growth retardation); distinctive malformations of the skull and facial (craniofacial) region; a short neck; and/or structural defects of the heart that are present at birth (congenital heart defects). Several cases have also been reported in which affected individuals have some features of DiGeorge syndrome (DGS). DGS is a congenital disorder characterized by underdevelopment or absence of the thymus and parathyroid glands, potentially causing abnormalities of the immune system, deficient production of parathyroid hormone (hypoparathyroidism), a heart defect, and associated findings. In many cases, chromosome 10, monosomy 10p appears to occur spontaneously (de novo) for unknown reasons.
Supporting Organizations
Alexander Graham Bell Association for the Deaf and Hard of Hearing
- 3417 Volta Place NW
- Washington, DC 20007-2778
- United States
- Tel: (202)337-5220
- Fax: (202)337-8314
- Tel: (866)337-5220
- Email: info@agbell.org
- Website: http://www.agbell.org
AmeriFace
- PO Box 751112
- Las Vegas, NV 89136
- USA
- Tel: (702)769-9264
- Fax: (702)341-5351
- Tel: (888)486-1209
- Email: info@ameriface.org
- Website: http://www.ameriface.org
American Heart Association
- 7272 Greenville Avenue
- Dallas, TX 75231
- Tel: (214)784-7212
- Fax: (214)784-1307
- Tel: (800)242-8721
- Email: Review.personal.info@heart.org
- Website: http://www.heart.org
Children's Craniofacial Association
- 13140 Coit Road
- Suite 517
- Dallas, TX 75240
- USA
- Tel: (214)570-9099
- Fax: (214)570-8811
- Tel: (800)535-3643
- Email: contactCCA@ccakids.com
- Website: http://www.ccakids.com
Chromosome Disorder Outreach, Inc.
- P.O. Box 724
- Boca Raton, FL 33429-0724
- USA
- Tel: (561)395-4252
- Fax: (561)395-4252
- Email: info@chromodisorder.org
- Website: http://www.chromodisorder.org/
Craniofacial Foundation of America
- 975 East Third Street
- Chattanooga, TN 37403
- Tel: (423)778-9176
- Fax: (423)778-8172
- Tel: (800)418-3223
- Email: terry.smyth@erlanger.org
- Website: http://www.craniofacialfoundation.org/www
European Society for Immunodeficiencies
- 1-3 rue de Chantepoulet
- Geneva, CH 1211
- Switzerland
- Tel: 410229080484
- Fax: 41229069140
- Email: esid@kenes.com
- Website: http://www.esid.org
Genetic and Rare Diseases (GARD) Information Center
- PO Box 8126
- Gaithersburg, MD 20898-8126
- Tel: (301)251-4925
- Fax: (301)251-4911
- Tel: (888)205-2311
- Website: http://rarediseases.info.nih.gov/GARD/
Immune Deficiency Foundation
- 110 West Road
- Suite 300
- Towson, MD 21204
- Tel: (410)321-6647
- Fax: (410)321-9165
- Tel: (800)296-4433
- Email: idf@primaryimmune.org
- Website: http://www.primaryimmune.org
March of Dimes
- 1275 Mamaroneck Avenue
- White Plains, NY 10605
- Tel: (914)997-4488
- Fax: (914)997-4763
- Email: AskUs@marchofdimes.org or preguntas@nacersano.org
- Website: http://www.marchofdimes.org and nacersano.org
NIH/National Institute of Diabetes, Digestive & Kidney Diseases
- Office of Communications & Public Liaison
- Bldg 31, Rm 9A06
- Bethesda, MD 20892-2560
- Tel: (301)496-3583
- Email: NDDIC@info.niddk.nih.gov
- Website: http://www2.niddk.nih.gov/
NIH/National Institute on Deafness and Other Communication Disorders
- 31 Center Drive, MSC 2320
- Communication Avenue
- Bethesda, MD 20892-3456
- Tel: (301)402-0900
- Fax: (301)907-8830
- Tel: (800)241-1044
- Email: nidcdinfo@nidcd.nih.gov
- Website: http://www.nidcd.nih.gov
The Arc
- 1825 K Street NW, Suite 1200
- Washington, DC 20006
- Tel: (202)534-3700
- Fax: (202)534-3731
- Tel: (800)433-5255
- Email: info@thearc.org
- Website: http://www.thearc.org
UNIQUE - Rare Chromosome Disorder Support Group
- G1 The Stables
- Station Road West
- Oxted, RH8 9EE
- United Kingdom
- Tel: 0044 (0)1883 723356
- Email: info@rarechromo.org
- Website: http://www.rarechromo.org/html/home.asp
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.
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This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
Last Updated: 3/16/2011
Copyright 2011 National Organization for Rare Disorders, Inc.
