Indole-3-carbinol is one of the major anticancer substances found in cruciferous (cabbage family) vegetables. It is a member of the class of sulfur-containing chemicals called glucosinolates.1 It is formed from parent compounds whenever cruciferous vegetables are crushed or cooked.2 , 3
How It Works
How to Use It
Based upon preliminary studies it is estimated that the minimum amount required for the prevention of breast cancer is 300 to 400 mg daily.4
Where to Find It
Indole-3-carbinol is found in highest concentrations in broccoli, but is also found in other cruciferous vegetables, such as cauliflower, cabbage, and kale.
As indole-3-carbinol is not an essential nutrient, no deficiency state exists.
Interactions with Supplements, Foods, & Other Compounds
Interactions with Medicines
1. Stoewsand GS. Bioactive organosulfur phytochemicals in Brassica oleracea vegetables—a review. Food Chem Toxicol 1995;33:537-43 [review].
2. Broadbent TA, Broadbent HS. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl)indole. [Part I]. Curr Med Chem 1998;5:337-52.
3. Broadbent TA, Broadbent HS. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl)indole. [Part II]. Curr Med Chem 1998;5:469-91.
4. Wong GY, Bradlow L, Sepkovic D, et al. Dose-ranging study of indole-3-carbinol for breast cancer prevention. J Cell Biochem Suppl 1997;28-29:111-6.
Last Review: 03-18-2015
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