Brain Natriuretic Peptide (BNP) Test

Test Overview

A brain natriuretic peptide (BNP) test measures the amount of the BNP hormone in your blood. BNP is made by your heart and shows how well your heart is working. Normally, only a low amount of BNP is found in your blood. But if your heart has to work harder than usual over a long period of time, such as from heart failure , the heart releases more BNP, increasing the blood level of BNP.

Why It Is Done

The brain natriuretic peptide (BNP) test is used to:

Check your risk for getting heart failure.
Check for heart failure. A doctor may think you have heart failure if you are having problems such as trouble breathing and swelling (edema) in the arms or legs.
Find out how severe heart failure is.

How To Prepare

You do not need to do anything before you have this test.

Talk to your doctor about any concerns you have regarding the need for the test, its risks, how it will be done, or what the results will mean. To help you understand the importance of this test, fill out the medical test information form .

How It Is Done

The health professional drawing your blood will:

Wrap an elastic band around your upper arm to stop the flow of blood. This makes the veins below the band larger so it is easier to put a needle into the vein.
Clean the needle site with alcohol.
Put the needle into the vein. More than one needle stick may be needed.
Attach a tube to the needle to fill it with blood.
Remove the band from your arm when enough blood is collected.
Apply a gauze pad or cotton ball over the needle site as the needle is removed.
Put pressure on the site and then put on a bandage.

How It Feels

You may feel nothing at all from the needle puncture, or you may feel a brief sting or pinch as the needle goes through the skin. Some people feel a stinging pain while the needle is in the vein. But many people do not feel any pain (or have only minor discomfort) once the needle is positioned in the vein. The amount of pain you feel depends on the skill of the health professional drawing the blood, the condition of your veins, and your sensitivity to pain.

Risks

There is very little risk of complications from having blood drawn from a vein.

You may develop a small bruise at the puncture site. You can reduce the risk of bruising by keeping pressure on the site for several minutes after the needle is withdrawn.
In rare cases, the vein may become inflamed after the blood sample is taken. This condition is called phlebitis and is usually treated with a warm compress applied several times daily.

Results

A brain natriuretic peptide (BNP) test measures the amount of the BNP hormone in the blood.

Normal BNP values are higher in women than in men. BNP values normally increase with age but may stay within a normal range unless heart failure is present.

The normal values listed here—called a reference range—are just a guide. These ranges vary from lab to lab, and your lab may have a different range for what's normal. Your lab report should contain the range your lab uses. Also, your doctor will evaluate your results based on your health and other factors. This means that a value that falls outside the normal values listed here may still be normal for you or your lab.

Your doctor will evaluate your results based on your age and gender. In general, normal values for BNP are less than 100 picograms per milliliter ( pg/mL ) or less than 100 nanograms per liter ( ng/L ).^{footnote 1}

The amount of a related substance, called N-terminal pro brain-natriuretic peptide (NT-proBNP), may be measured instead of BNP. The results from the NT-proBNP test are different than those from the BNP test but provide similar information. Normal values for NT-proBNP are less than 400 pg/mL or less than 400 ng/L.^{footnote 1}

High values

A high value of BNP in the blood:

May mean an increased amount of fluid or high pressure inside the heart.
May be used to help determine the severity of heart failure.
May mean a higher chance of death in people with heart failure.

What Affects the Test

Reasons you may not be able to have the test or why the results may not be helpful include:

Having lung disease, such as emphysema or chronic obstructive pulmonary disease (COPD).
Having kidney disease, kidney dialysis, or a heart attack.

What To Think About

A BNP level may stay above the normal BNP level even when a heart failure treatment is working well. Your doctor will use your physical exam and other tests, along with your BNP level, to check your heart.

Related Information

Medical Tests: Questions to Ask the Doctor

References

Citations

Fischbach F, Dunning MB III (2015). A Manual of Laboratory and Diagnostic Tests, 9th ed. Philadelphia: Wolters Kluwer Health.

Other Works Consulted

Chow SL, et al. (2017). Role of biomarkers for the prevention, assessment, and management of heart failure: A scientific statement from the American Heart Association. Circulation, published online April 26, 2017. DOI: 10.1161/CIR.0000000000000490. Accessed May 1, 2017.

Chernecky CC, Berger BJ (2013). Laboratory Tests and Diagnostic Procedures, 6th ed. St. Louis: Saunders.

Fischbach F, Dunning MB III (2015). A Manual of Laboratory and Diagnostic Tests, 9th ed. Philadelphia: Wolters Kluwer Health.

Pagana KD, Pagana TJ (2010). Mosby's Manual of Diagnostic and Laboratory Tests, 4th ed. St. Louis: Mosby Elsevier.

Yancy CW, et al. (2013). 2013 ACCF/AHA Guideline for the management of heart failure: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology, 62(16): e147–e239.

Credits

Current as of: December 16, 2019

Author: Healthwise Staff
Medical Review: E. Gregory Thompson MD - Internal Medicine
Martin J. Gabica MD - Family Medicine
Adam Husney MD - Family Medicine
Stephen Fort MD, MRCP, FRCPC - Interventional Cardiology

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